Scientist, Molecular Biology at Bullseye Biosciences

Job description

Scientist, Molecular Biology

See the job posting here on LinkedIn

Embarking on a rewarding journey to tackle monumental challenges in human health. Company Description:

Bullseye Biosciences is at the vanguard of directed evolution, innovating on therapeutic discovery for critical targets in oncology, immunology, and metabolism. The “Archer” platform has been established from foundational work at our academic co-founder Dr Chory at Duke. We seek to deploy this technology against intracellular protein-protein interactions (PPIs) which are too large for small molecules and inaccessible to biologics. PPIs are extremely well validated drivers of human disease whose potential as drug targets remains a high unmet need

Your expertise in molecular biology will not just advance our research, but also contribute significantly to the development of life-changing treatments. Role Description:

Come join us as a molecular biologist in building a new generation of drugs against historically challenging targets using our directed evolution discovery engine! This role will be instrumental in the design and wet lab execution of both experimental and synthetic biology work. The Archer screening platform and subsequent hit testing relies on careful design of reporter “gene circuits” with multiple inducible components for precise control of the system. Working with the head of research, this scientist would be accountable for the design and validation of novel gene circuits against challenging human disease targets. The molecular biology scientist would work with our automation scientists and academic founder lab to implement these circuits on high-through continuous evolution systems. They would also have the opportunity to continue supporting these targets through early drug discovery efforts. As a member of a small start-up everyone makes major contributions to the direction and success of the company!

Your scientific acumen in molecular biology will be the cornerstone of our research and development efforts. Key Qualifications and responsibilities:

• Molecular biology laboratory techniques including: bacterial culture, PCR, cloning, protein blot analysis, assay development (western blot, ELISA, luminescence), and phage propagation
• Expertise with plasmid/construct design and cloning techniques. Construct design and tracking using Geneious and Benchling. Sequencing by Sanger for confirmation
• Understanding of plasmid components, such as inducible promoters and RBS, is important.
• Knowledge of biology and molecular biology related to cancer, immunology, or synthetic biology
• Collaborate with cross-functional teams, including automation scientists and academic labs, to advance our high-throughput continuous evolution systems
• Attention to detail and accuracy in laboratory work including familiarity with ELN programs
• Strong analytical and problem-solving skills.
• Proficiency in data analysis and graphing software, including Graphpad and Spotfire, as well as Excel
• Experience with RNA/DNA NGS and automation is a plus
• Ability to work independently and as a team
• Good organizational and time management skills
• PhD with at least 2 years of experience, or a Master's degree with at least 4 years of experience, in molecular biology or a related field

Joining Bullseye Biosciences means more than a job—it’s a chance to own a piece of the innovation you help create, within an equitable and inclusive workplace that celebrates each milestone alongside you. What we offer:

• Receive competitive salary and significant equity compensation, granting you a share in the company’s success and ownership in the innovations you help bring to life
• Contribution to the company at multiple levels and help drive its growth as a part of the early founding team
• Experience in a early start-up environment with exposure to multiple facets of the business
• Opportunities for exposure to numerous startups and founders within the thriving biotech environment of the Harvard Life Labs space

If you are ready to make a tangible impact on the future of drug discovery and thrive in a fast-paced, innovative environment, we welcome you to apply and help shape the journey of Bullseye Biosciences!

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law

To successfully perform this job, candidates must be able to satisfactorily fulfill each responsibility. The above job description represents the necessary knowledge, skills, and abilities. Reasonable accommodations may be provided to enable individuals with disabilities to perform the described functions