Research Associate, Protein Engineering and Expression

Job description

Please apply here: https://jobs.polymer.co/matrisome-bio/31519#apply

Matrisome Bio is a founder-led, stealth-mode venture-backed biotech company focused on improving the lives of patients with chronic diseases such as cancer and fibrosis. Our transformative platform enables the development of novel therapeutic approaches by leveraging the properties of the extracellular matrix (ECM). With an initial focus on oncology, we aim to change the paradigm of targeted therapies across chronic diseases. Matrisome Bio’s founding team and scientific advisors represent leaders in academia, industry, and biotech entrepreneurship.   

If you are interested in changing the landscape of cancer therapy and working in a dynamic, highly motivated, and diverse team, come join us! 

Position Summary 

As a Research Associate at Matrisome Bio, you will be an integral part of our growing research and development team to support oncology drug development programs. We are seeking a motivated scientist to play a key role in building Matrisome’s internal capabilities in protein engineering, production/purification, and characterization. This role is a unique opportunity to join an early-stage, fast-paced start-up founded by world renowned experts in ECM biology, oncology, and bioengineering. This is an on-site position based in Cambridge, MA. 

Essential Duties include (but are not limited to): 

• Collaborate with scientists to design, produce, and characterize engineered proteins in bacterial and mammalian systems 
• Establish, optimize, and execute protocols for protein production and engineering using state-of-the-art equipment and methods 
• Take a proactive role in troubleshooting experiments and overcoming scientific barriers 
• Work together with colleagues, contract research organizations, and academic collaborators 
• Ensure smooth lab operations: maintain laboratory equipment and restock supplies as needed 
• Document experiments, record data in electronic lab notebooks and company databases, and communicate clearly and precisely with various stakeholders 
• Provide and share regular updates at internal meetings including summarizing data and study reports 

Qualifications: 

• A Bachelor’s or Master’s degree in biology, biochemistry, biomolecular/biomedical engineering, pharmacology, or related fields 
• Experience with standard molecular and cellular biology techniques (e.g. cloning, plasmid purification, DNA analysis, cell culture) 
• Experience with protein expression in mammalian and/or bacterial systems 
• Experience with protein purification and characterization methods (e.g. affinity chromatography, SDS-PAGE, FPLC, HPLC, LC-MS) 
• Proficient in Excel, PowerPoint, and GraphPad Prism for data entry, analysis, and presentation 
• Ability to work both independently and collaboratively as part of a team 
• High level of integrity and commitment to quality is essential 

• Strong written and oral communication skills 

   

What We Offer 

• Opportunity to build a transformative platform as one of the first employees in a fast-paced, entrepreneurial, team-focused work environment 
• Comprehensive benefits package including health, dental and vision coverage, 401k plan, company paid holidays, paid time off, paid parental leave benefit, dependent care FSA, and equity/stock options  
• Professional development through mentorship and training while working together to meet the company goals 
• A dynamic start-up ecosystem with weekly social events and networking opportunities 

The employee must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship. The Employer retains the right to change or assign other duties to this position. Working conditions may include prolonged periods of being at a stationary desk or work computer, occasionally adjusting, handling, or moving objects up to 30 pounds, assessing the accuracy, neatness, and/or thoroughness of the work assigned and communicating with others to exchange information. 

 Matrisome Bio requires that all employees be fully vaccinated against COVID-19 and provide proof thereof or receive an approved medical or religious exemption. 

 Matrisome Bio is based in Massachusetts with an office location in Cambridge, MA. Matrisome is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.